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Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study this regulatory paradigm. Ectopic overexpression of HuR potently enhanced the translation and cytoplas...

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Detalhes bibliográficos
Main Authors: Yi, Jie, Chang, Na, Liu, Xinwen, Guo, Gaier, Xue, Lixiang, Tong, Tanjun, Gorospe, Myriam, Wang, Wengong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836555/
https://ncbi.nlm.nih.gov/pubmed/20007147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1114
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