HuR Uses AUF1 as a Cofactor To Promote p16(INK4) mRNA Decay

In this study, we show that HuR destabilizes p16(INK4) mRNA. Although the knockdown of HuR or AUF1 increased p16 expression, concomitant AUF1 and HuR knockdown had a much weaker effect. The knockdown of Ago2, a component of the RNA-induced silencing complex (RISC), stabilized p16 mRNA. The knockdown...

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Main Authors: Chang, Na, Yi, Jie, Guo, Gaier, Liu, Xinwen, Shang, Yongfeng, Tong, Tanjun, Cui, Qinghua, Zhan, Ming, Gorospe, Myriam, Wang, Wengong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916395/
https://ncbi.nlm.nih.gov/pubmed/20498276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00169-10
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