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Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study this regulatory paradigm. Ectopic overexpression of HuR potently enhanced the translation and cytoplas...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836555/ https://ncbi.nlm.nih.gov/pubmed/20007147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1114 |
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