Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study this regulatory paradigm. Ectopic overexpression of HuR potently enhanced the translation and cytoplas...

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Bibliografiske detaljer
Main Authors: Yi, Jie, Chang, Na, Liu, Xinwen, Guo, Gaier, Xue, Lixiang, Tong, Tanjun, Gorospe, Myriam, Wang, Wengong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836555/
https://ncbi.nlm.nih.gov/pubmed/20007147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1114
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