Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study this regulatory paradigm. Ectopic overexpression of HuR potently enhanced the translation and cytoplas...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yi, Jie, Chang, Na, Liu, Xinwen, Guo, Gaier, Xue, Lixiang, Tong, Tanjun, Gorospe, Myriam, Wang, Wengong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2010
Gaiak:
Molecular Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836555/
https://ncbi.nlm.nih.gov/pubmed/20007147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1114
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