Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence

Cellular aging is accompanied by alterations in gene expression patterns. Here, using two models of replicative senescence, we describe the influence of the RNA-binding protein HuR in regulating the expression of several genes whose expression decreases during senescence. We demonstrate that HuR lev...

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Detalhes bibliográficos
Main Authors: Wang, Wengong, Yang, Xiaoling, Cristofalo, Vincent J., Holbrook, Nikki J., Gorospe, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87308/
https://ncbi.nlm.nih.gov/pubmed/11486028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.5889-5898.2001
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