Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence

Cellular aging is accompanied by alterations in gene expression patterns. Here, using two models of replicative senescence, we describe the influence of the RNA-binding protein HuR in regulating the expression of several genes whose expression decreases during senescence. We demonstrate that HuR lev...

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Autors principals: Wang, Wengong, Yang, Xiaoling, Cristofalo, Vincent J., Holbrook, Nikki J., Gorospe, Myriam
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87308/
https://ncbi.nlm.nih.gov/pubmed/11486028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.5889-5898.2001
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