Loss of CARM1 is linked to reduced HuR function in replicative senescence

BACKGROUND: The co-activator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of HuR. However, the functional impact of this modification is not fully understood. Here, we investigated the influence of HuR methylation by CARM1 upon the turnover of HuR target mRNAs encoding s...

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Detaylı Bibliyografya
Asıl Yazarlar: Pang, Lijun, Tian, Haiyan, Chang, Na, Yi, Jie, Xue, Lixiang, Jiang, Bin, Gorospe, Myriam, Zhang, Xiaowei, Wang, Wengong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718661/
https://ncbi.nlm.nih.gov/pubmed/23837869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-14-15
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