Carboetomidate: A Pyrrole Analogue of Etomidate Designed Not To Suppress Adrenocortical Function

BACKGROUND: Etomidate is a sedative-hypnotic that is often used in critically ill patients because it provides superior hemodynamic stability. However it also binds with high affinity to 11β-hydroxylase, potently suppressing synthesis of steroids by the adrenal gland that are necessary for survival....

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Autori principali: Cotten, Joseph F., Forman, Stuart A., Laha, Joydev K., Cuny, Gregory D., Husain, S. Shaukat, Miller, Keith W., Nguyen, Hieu H., Kelly, Elizabeth W., Stewart, Deirdre, Liu, Aiping, Raines, Douglas E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830733/
https://ncbi.nlm.nih.gov/pubmed/20179500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3181cf40ed
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