Carboetomidate: An Analog of Etomidate That Interacts Weakly with 11β-Hydroxylase

BACKGROUND: Carboetomidate is a pyrrole etomidate analog that is 3 orders of magnitude less potent an inhibitor of in vitro cortisol synthesis than etomidate and does not inhibit in vivo steroid production. Although carboetomidate's reduced functional effect on steroid synthesis is thought to r...

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Auteurs principaux: Shanmugasundararaj, Sivananthaperumal, Zhou, Xiaojuan, Neunzig, Jens, Bernhardt, Rita, Cotten, Joseph F., Ge, Rile, Miller, Keith W., Raines, Douglas E.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836822/
https://ncbi.nlm.nih.gov/pubmed/23492967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e31828b3637
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