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Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron

Intracellular α-synuclein (α-syn) aggregates are the pathological hallmark in several neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Recent evidence suggests that small oligomeric aggregates rather than large amyloid fibrils repr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hillmer, Andreas S., Putcha, Preeti, Levin, Johannes, Högen, Tobias, Hyman, Bradley T., Kretzschmar, Hans, McLean, Pamela J., Giese, Armin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812586/
https://ncbi.nlm.nih.gov/pubmed/19914207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.11.080
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