Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers

BACKGROUND: In several neurodegenerative diseases, hyperphosphorylation at position Ser129 is found in fibrillar deposits of alpha-synuclein (asyn), implying a pathophysiological role of asyn phosphorylation in neurodegeneration. However, recent animal models applying asyn phosphorylation mimics dem...

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Bibliografiset tiedot
Päätekijät: Nübling, Georg Sebastian, Levin, Johannes, Bader, Benedikt, Lorenzl, Stefan, Hillmer, Andreas, Högen, Tobias, Kamp, Frits, Giese, Armin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2014
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Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049638/
https://ncbi.nlm.nih.gov/pubmed/24911099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098906
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