Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers

BACKGROUND: In several neurodegenerative diseases, hyperphosphorylation at position Ser129 is found in fibrillar deposits of alpha-synuclein (asyn), implying a pathophysiological role of asyn phosphorylation in neurodegeneration. However, recent animal models applying asyn phosphorylation mimics dem...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Nübling, Georg Sebastian, Levin, Johannes, Bader, Benedikt, Lorenzl, Stefan, Hillmer, Andreas, Högen, Tobias, Kamp, Frits, Giese, Armin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049638/
https://ncbi.nlm.nih.gov/pubmed/24911099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098906
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi