Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas’ disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival, cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A recent quantitative high-throughput screen of cr...

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Detaylı Bibliyografya
Asıl Yazarlar: Mott, Bryan T., Ferreira, Rafaela S., Simeonov, Anton, Jadhav, Ajit, Ang, Kenny Kean-Hooi, Leister, William, Shen, Min, Silveira, Julia T., Doyle, Patricia S., Arkin, Michelle R., McKerrow, James H., Inglese, James, Austin, Christopher P., Thomas, Craig J., Shoichet, Brian K., Maloney, David J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804034/
https://ncbi.nlm.nih.gov/pubmed/19908842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901069a
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