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Identification of a New Class of Nonpeptidic Inhibitors of Cruzain
Cruzain is the major cysteine protease of T. cruzi, which is the causative agent of Chagas’ disease and is a promising target for the development of new chemotherapy. With the goal of developing potent nonpeptidic inhibitors of cruzain, the Substrate Activity Screening (SAS) method was used to scree...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765048/ https://ncbi.nlm.nih.gov/pubmed/18435536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710254m |
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