The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion

Trypanosoma cruzi is the causative agent of Chagas' disease. Novel chemotherapy with the drug K11777 targets the major cysteine protease cruzain and disrupts amastigote intracellular development. Nevertheless, the biological role of the protease in infection and pathogenesis remains unclear as...

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Autors principals: Doyle, Patricia S., Zhou, Yuan M., Hsieh, Ivy, Greenbaum, Doron C., McKerrow, James H., Engel, Juan C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164631/
https://ncbi.nlm.nih.gov/pubmed/21909255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002139
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