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Identification of a New Class of Nonpeptidic Inhibitors of Cruzain

Cruzain is the major cysteine protease of T. cruzi, which is the causative agent of Chagas’ disease and is a promising target for the development of new chemotherapy. With the goal of developing potent nonpeptidic inhibitors of cruzain, the Substrate Activity Screening (SAS) method was used to scree...

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Detalhes bibliográficos
Main Authors: Brak, Katrien, Doyle, Patricia S., McKerrow, James H., Ellman, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765048/
https://ncbi.nlm.nih.gov/pubmed/18435536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710254m
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