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Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei. The cysteine proteases of T.brucei have been shown to be crucial for parasite replication and represent an attractive point for therapeutic intervention. Herein we describe the synthesis of a series of thiose...

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Détails bibliographiques
Auteurs principaux: Mallari, Jeremy P., Shelat, Anang, Kosinski, Aaron, Caffrey, Conor R., Connelly, Michele, Zhu, Fangyi, McKerrow, James H., Guy, R. Kiplin
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435229/
https://ncbi.nlm.nih.gov/pubmed/18420405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.083
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