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Structure-guided development of selective TbcatB inhibitors
The trypanosomal cathepsin TbcatB is essential for parasite survival and is an attractive therapeutic target. Herein we report the structure-guided development of TbcatB inhibitors with specificity relative to rhodesain and human cathepsins B and L. Inhibitors were tested for enzymatic activity, try...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762491/ https://ncbi.nlm.nih.gov/pubmed/19769357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900908p |
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