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Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB
Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei. The cysteine proteases of T.brucei have been shown to be crucial for parasite replication and represent an attractive point for therapeutic intervention. Herein we describe the synthesis of a series of thiose...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435229/ https://ncbi.nlm.nih.gov/pubmed/18420405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.083 |
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