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Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei. The cysteine proteases of T.brucei have been shown to be crucial for parasite replication and represent an attractive point for therapeutic intervention. Herein we describe the synthesis of a series of thiose...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mallari, Jeremy P., Shelat, Anang, Kosinski, Aaron, Caffrey, Conor R., Connelly, Michele, Zhu, Fangyi, McKerrow, James H., Guy, R. Kiplin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435229/
https://ncbi.nlm.nih.gov/pubmed/18420405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.083
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