Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain

[Image: see text] Dipeptidyl nitroalkenes are potent reversible inhibitors of cysteine proteases. Inhibitor 11 resulted to be the most potent one with K(i) values of 0.49 and 0.44 nM against rhodesain and cruzain, respectively. According to enzymatic dilution and dialysis experiments, as well as com...

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Publicado en:ACS Med Chem Lett
Autores principales: Latorre, Antonio, Schirmeister, Tanja, Kesselring, Jochen, Jung, Sascha, Johé, Patrick, Hellmich, Ute A., Heilos, Anna, Engels, Bernd, Krauth-Siegel, R. Luise, Dirdjaja, Natalie, Bou-Iserte, Lledó, Rodríguez, Santiago, González, Florenci V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150692/
https://ncbi.nlm.nih.gov/pubmed/27994740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00276
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