Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain

[Image: see text] Dipeptidyl nitroalkenes are potent reversible inhibitors of cysteine proteases. Inhibitor 11 resulted to be the most potent one with K(i) values of 0.49 and 0.44 nM against rhodesain and cruzain, respectively. According to enzymatic dilution and dialysis experiments, as well as com...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Latorre, Antonio, Schirmeister, Tanja, Kesselring, Jochen, Jung, Sascha, Johé, Patrick, Hellmich, Ute A., Heilos, Anna, Engels, Bernd, Krauth-Siegel, R. Luise, Dirdjaja, Natalie, Bou-Iserte, Lledó, Rodríguez, Santiago, González, Florenci V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150692/
https://ncbi.nlm.nih.gov/pubmed/27994740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00276
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados