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Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas’ disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival, cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A recent quantitative high-throughput screen of cr...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Mott, Bryan T., Ferreira, Rafaela S., Simeonov, Anton, Jadhav, Ajit, Ang, Kenny Kean-Hooi, Leister, William, Shen, Min, Silveira, Julia T., Doyle, Patricia S., Arkin, Michelle R., McKerrow, James H., Inglese, James, Austin, Christopher P., Thomas, Craig J., Shoichet, Brian K., Maloney, David J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804034/
https://ncbi.nlm.nih.gov/pubmed/19908842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901069a
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