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Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas’ disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival, cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A recent quantitative high-throughput screen of cr...

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Bibliografiske detaljer
Main Authors: Mott, Bryan T., Ferreira, Rafaela S., Simeonov, Anton, Jadhav, Ajit, Ang, Kenny Kean-Hooi, Leister, William, Shen, Min, Silveira, Julia T., Doyle, Patricia S., Arkin, Michelle R., McKerrow, James H., Inglese, James, Austin, Christopher P., Thomas, Craig J., Shoichet, Brian K., Maloney, David J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804034/
https://ncbi.nlm.nih.gov/pubmed/19908842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901069a
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