Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas’ disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival, cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A recent quantitative high-throughput screen of cr...

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Bibliografiset tiedot
Päätekijät: Mott, Bryan T., Ferreira, Rafaela S., Simeonov, Anton, Jadhav, Ajit, Ang, Kenny Kean-Hooi, Leister, William, Shen, Min, Silveira, Julia T., Doyle, Patricia S., Arkin, Michelle R., McKerrow, James H., Inglese, James, Austin, Christopher P., Thomas, Craig J., Shoichet, Brian K., Maloney, David J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804034/
https://ncbi.nlm.nih.gov/pubmed/19908842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901069a
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