Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.

In paroxysmal nocturnal hemoglobinuria (PNH), an acquired hemolytic anemia, deficiency of decay accelerating factor (DAF) renders blood cells susceptible to increased deposition of autologous complement activation fragments (C3b) and complemented-mediated injury. To investigate the mechanism of the...

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Bibliographic Details
Main Authors: Stafford, H A, Tykocinski, M L, Lublin, D M, Holers, V M, Rosse, W F, Atkinson, J P, Medof, M E
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC279660/
https://ncbi.nlm.nih.gov/pubmed/2448783
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