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Structural Requirements for a Lipoamino Acid in Modulating the Anticonvulsant Activities of the Systemically-Active Galanin Analogs
Introduction of lipoamino acid (LAA), Lys-palmitoyl, and cationization into a series of galanin analogs yielded systemically-active anticonvulsant compounds. To study the relationship between the LAA structure and anticonvulsant activity, orthogonally protected LAAs were synthesized in which the Lys...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765488/ https://ncbi.nlm.nih.gov/pubmed/19199479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801397w |
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