Structural Requirements for a Lipoamino Acid in Modulating the Anticonvulsant Activities of the Systemically-Active Galanin Analogs

Introduction of lipoamino acid (LAA), Lys-palmitoyl, and cationization into a series of galanin analogs yielded systemically-active anticonvulsant compounds. To study the relationship between the LAA structure and anticonvulsant activity, orthogonally protected LAAs were synthesized in which the Lys...

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Hlavní autoři: Zhang, Liuyin, Robertson, Charles R., Green, Brad R., Pruess, Timothy H., White, H. Steve, Bulaj, Grzegorz
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765488/
https://ncbi.nlm.nih.gov/pubmed/19199479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801397w
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