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Engineering Galanin Analogues that Discriminate Between GalR1 and GalR2 Receptor Subtypes and Exhibit Anticonvulsant Activity Following Systemic Delivery
Galanin modulates seizures in the brain through two galanin receptor subtypes, GalR1 and GalR2. To generate systemically-active galanin receptor ligands that discriminate between GalR1 and GalR2, the GalR1-preferring analogue, Gal-B2 (or NAX 5055), was rationally redesigned to yield GalR2-preferring...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846716/ https://ncbi.nlm.nih.gov/pubmed/20121116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9018349 |
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