GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models

Galanin receptors type 1 (GalR1) and/or type 2 (GalR2) represent unique pharmacological targets for treatment of seizures and epilepsy. Previous studies have shown that the endogenous peptide ligand galanin exerts powerful anticonvulsant effect through activation of these two G protein-coupled recep...

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Bibliografiska uppgifter
Huvudupphovsmän: Lu, Xiaoying, Roberts, Edward, Xia, Fengcheng, Sanchez-Alavez, Manuel, Liu, Tianyu, Baldwin, Roger, Wu, Stephanie, Chang, James, Wasterlain, Claude G., Bartfai, Tamas
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930524/
https://ncbi.nlm.nih.gov/pubmed/20660766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008986107
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