microRNA-Mediated Messenger RNA Deadenylation Contributes to Translational Repression in Mammalian Cells

Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3′ untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening of the mRNA 3′ poly(A) tail, which contributes to t...

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Main Authors: Beilharz, Traude H., Humphreys, David T., Clancy, Jennifer L., Thermann, Rolf, Martin, David I. K., Hentze, Matthias W., Preiss, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728509/
https://ncbi.nlm.nih.gov/pubmed/19710908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006783
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