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microRNA-Mediated Messenger RNA Deadenylation Contributes to Translational Repression in Mammalian Cells

Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3′ untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening of the mRNA 3′ poly(A) tail, which contributes to t...

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Detalhes bibliográficos
Main Authors: Beilharz, Traude H., Humphreys, David T., Clancy, Jennifer L., Thermann, Rolf, Martin, David I. K., Hentze, Matthias W., Preiss, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728509/
https://ncbi.nlm.nih.gov/pubmed/19710908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006783
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