Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish

MicroRNA (miRNA) is a class of small noncoding RNA approximately 22 nt in length. Animal miRNA silences complementary mRNAs via translational inhibition, deadenylation, and mRNA degradation. However, the underlying molecular mechanisms remain unclear. A key question is whether these three outputs ar...

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Bibliographic Details
Main Authors: Mishima, Yuichiro, Fukao, Akira, Kishimoto, Tomoyoshi, Sakamoto, Hiroshi, Fujiwara, Toshinobu, Inoue, Kunio
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268308/
https://ncbi.nlm.nih.gov/pubmed/22232654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113350109
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