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microRNA-Mediated Messenger RNA Deadenylation Contributes to Translational Repression in Mammalian Cells

Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3′ untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening of the mRNA 3′ poly(A) tail, which contributes to t...

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מידע ביבליוגרפי
Main Authors: Beilharz, Traude H., Humphreys, David T., Clancy, Jennifer L., Thermann, Rolf, Martin, David I. K., Hentze, Matthias W., Preiss, Thomas
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2009
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728509/
https://ncbi.nlm.nih.gov/pubmed/19710908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006783
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