mRNA isoform diversity can obscure detection of miRNA-mediated control of translation

Reporter-based studies support inhibition of translation at the level of initiation as a substantial component of the miRNA mechanism, yet recent global analyses have suggested that they predominantly act through decreasing target mRNA stability. Cells commonly coexpress several processing isoforms...

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Bibliografiske detaljer
Main Authors: Clancy, Jennifer L., Wei, Grace H., Echner, Nicole, Humphreys, David T., Beilharz, Traude H., Preiss, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096034/
https://ncbi.nlm.nih.gov/pubmed/21467217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2567611
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