Structurally Simple, Potent, Plasmodium Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites

Third world nations require immediate access to inexpensive therapeutics to counter the high mortality inflicted by malaria. Here, we report a new class of antimalarial protein farnesyltransferase (PFT) inhibitors, designed with specific emphasis on simple molecular architecture, to facilitate easy...

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Hauptverfasser: Glenn, Matthew P., Chang, Sung-Youn, Hornéy, Carrie, Rivas, Kasey, Yokoyama, Kohei, Pusateri, Erin E., Fletcher, Steven, Cummings, Christopher G., Buckner, Frederick S., Pendyala, Prakash R., Chakrabarti, Debopam, Sebti, Saïd M., Gelb, Michael, Van Voorhis, Wesley C., Hamilton, Andrew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728208/
https://ncbi.nlm.nih.gov/pubmed/16970397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060081v
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