Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure—Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation

New chemotherapeutics are urgently needed to combat malaria. We previously reported on a novel series of antimalarial, ethylenediamine-based inhibitors of protein farnesyltransferase (PFT). In the current study, we designed and synthesized a series of second generation inhibitors, wherein the core e...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Fletcher, Steven, Cummings, Christopher G., Rivas, Kasey, Katt, William P., Hornéy, Carrie, Buckner, Frederick S., Chakrabarti, Debopam, Sebti, Saïd M., Gelb, Michael H., Van Voorhis, Wesley C., Hamilton, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049929/
https://ncbi.nlm.nih.gov/pubmed/18686940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800113p
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados