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Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

Protein farnesyltransferase (FTase) catalyzes an essential posttranslational lipid modification of more than 60 proteins involved in intracellular signal transduction networks. FTase inhibitors have emerged as a significant target for development of anticancer therapeutics and, more recently, for th...

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Bibliografske podrobnosti
Main Authors: Hast, Michael A., Fletcher, Steven, Cummings, Christopher G., Pusateri, Erin E., Blaskovich, Michelle A., Rivas, Kasey, Gelb, Michael H., Van Voorhis, Wesley C., Sebti, Said M., Hamilton, Andrew D., Beese, Lorena S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671474/
https://ncbi.nlm.nih.gov/pubmed/19246009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.01.014
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