Second Generation Tetrahydroquinoline-Based Protein Farnesyltransferase Inhibitors as Antimalarials

Substituted tetrahydroquinolines (THQs) have been previously identified as inhibitors of mammalian protein farnesyltransferase (PFT). Previously we showed that blocking PFT in the malaria parasite led to cell death and that THQ-based inhibitors are the most potent among several structural classes of...

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Detalhes bibliográficos
Main Authors: Bendale, Pravin, Olepu, Srinivas, Suryadevara, Praveen Kumar, Bulbule, Vivek, Rivas, Kasey, Nallan, Laxman, Smart, Brian, Yokoyama, Kohei, Ankala, Sudha, Pendyala, Prakash Rao, Floyd, David, Lombardo, Louis J., Williams, David K., Buckner, Frederick S., Chakrabarti, Debopam, Verlinde, Christophe L. M. J., Van Voorhis, Wesley C., Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894570/
https://ncbi.nlm.nih.gov/pubmed/17722901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0703340
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