Structurally Simple, Potent, Plasmodium Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites

Third world nations require immediate access to inexpensive therapeutics to counter the high mortality inflicted by malaria. Here, we report a new class of antimalarial protein farnesyltransferase (PFT) inhibitors, designed with specific emphasis on simple molecular architecture, to facilitate easy...

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Detalhes bibliográficos
Main Authors: Glenn, Matthew P., Chang, Sung-Youn, Hornéy, Carrie, Rivas, Kasey, Yokoyama, Kohei, Pusateri, Erin E., Fletcher, Steven, Cummings, Christopher G., Buckner, Frederick S., Pendyala, Prakash R., Chakrabarti, Debopam, Sebti, Saïd M., Gelb, Michael, Van Voorhis, Wesley C., Hamilton, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728208/
https://ncbi.nlm.nih.gov/pubmed/16970397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060081v
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