Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents

A potent class of anticancer, human farnesyltransferase (hFTase) inhibitors has been identified by “piggy-backing” on potent, antimalarial inhibitors of Plasmodium falciparum farnesyltransferase (PfFTase). On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally...

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Bibliographic Details
Main Authors: Fletcher, Steven, Keaney, Erin Pusateri, Cummings, Christopher G., Blaskovich, Michelle A., Hast, Michael A., Glenn, Matthew P., Chang, Sung-Youn, Bucher, Cynthia J., Floyd, Ryan J., Katt, William P., Gelb, Michael H., Van Voorhis, Wesley C., Beese, Lorena S., Sebti, Said M., Hamilton, Andrew D.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045627/
https://ncbi.nlm.nih.gov/pubmed/20822181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1001748
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