Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor ora...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Van Voorhis, Wesley C., Rivas, Kasey L., Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K., Bauer, Kevin D., Smart, Brian P., Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S., Hamilton, Andrew D., Williams, David K., Lombardo, Louis J., Floyd, David, Gelb, Michael H.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology (ASM) 2007
الموضوعات:
Experimental Therapeutics
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043286/
https://ncbi.nlm.nih.gov/pubmed/17606674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00246-07
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