Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor ora...

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Bibliografiset tiedot
Päätekijät: Van Voorhis, Wesley C., Rivas, Kasey L., Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K., Bauer, Kevin D., Smart, Brian P., Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S., Hamilton, Andrew D., Williams, David K., Lombardo, Louis J., Floyd, David, Gelb, Michael H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2007
Aiheet:
Experimental Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043286/
https://ncbi.nlm.nih.gov/pubmed/17606674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00246-07
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