Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor ora...

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Detalles Bibliográficos
Main Authors: Van Voorhis, Wesley C., Rivas, Kasey L., Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K., Bauer, Kevin D., Smart, Brian P., Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S., Hamilton, Andrew D., Williams, David K., Lombardo, Louis J., Floyd, David, Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2007
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043286/
https://ncbi.nlm.nih.gov/pubmed/17606674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00246-07
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