Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor ora...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Van Voorhis, Wesley C., Rivas, Kasey L., Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K., Bauer, Kevin D., Smart, Brian P., Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S., Hamilton, Andrew D., Williams, David K., Lombardo, Louis J., Floyd, David, Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043286/
https://ncbi.nlm.nih.gov/pubmed/17606674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00246-07
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados