Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor ora...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Van Voorhis, Wesley C., Rivas, Kasey L., Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K., Bauer, Kevin D., Smart, Brian P., Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S., Hamilton, Andrew D., Williams, David K., Lombardo, Louis J., Floyd, David, Gelb, Michael H.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology (ASM) 2007
Θέματα:
Experimental Therapeutics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043286/
https://ncbi.nlm.nih.gov/pubmed/17606674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00246-07
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