Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure—Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation

New chemotherapeutics are urgently needed to combat malaria. We previously reported on a novel series of antimalarial, ethylenediamine-based inhibitors of protein farnesyltransferase (PFT). In the current study, we designed and synthesized a series of second generation inhibitors, wherein the core e...

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Autores principales: Fletcher, Steven, Cummings, Christopher G., Rivas, Kasey, Katt, William P., Hornéy, Carrie, Buckner, Frederick S., Chakrabarti, Debopam, Sebti, Saïd M., Gelb, Michael H., Van Voorhis, Wesley C., Hamilton, Andrew D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049929/
https://ncbi.nlm.nih.gov/pubmed/18686940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800113p
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