Position-specific trapping of topoisomerase I–DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine

DNA topoisomerase I (top1) is the target of potent anticancer agents, including camptothecins and DNA intercalators, which reversibly stabilize (trap) top1 catalytic intermediates (cleavage complexes). The aim of the present study was to define the structural relationship between the site(s) of cova...

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Detalhes bibliográficos
Main Authors: Pommier, Yves, Laco, Gary S., Kohlhagen, Glenda, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27093/
https://ncbi.nlm.nih.gov/pubmed/10995470
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