Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents

DNA topoisomerase II (Top2) is the target of some of the most effective anticancer DNA intercalators. To determine the effect of intercalating ligands at defined positions relative to a known DNA cleavage site for human Top2α, we synthesized oligodeoxynucleotides containing single trans-opened benzo...

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Detalhes bibliográficos
Main Authors: Khan, Qasim A., Kohlhagen, Glenda, Marshall, Richard, Austin, Caroline A., Kalena, Govind P., Kroth, Heiko, Sayer, Jane M., Jerina, Donald M., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC218786/
https://ncbi.nlm.nih.gov/pubmed/14523238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2032456100
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