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Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase ι

Human DNA polymerase ι (polι) is a Y-family polymerase whose cellular function is presently unknown. Here, we report on the ability of polι to bypass various stereoisomers of benzo[a]pyrene (BaP) diol epoxide (DE) and benzo[c]phenanthrene (BcPh) DE adducts at deoxyadenosine (dA) or deoxyguanosine (d...

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Bibliografische gegevens
Hoofdauteurs: Frank, Ekaterina G., Sayer, Jane M., Kroth, Heiko, Ohashi, Eiji, Ohmori, Haruo, Jerina, Donald M., Woodgate, Roger
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137958/
https://ncbi.nlm.nih.gov/pubmed/12466554
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