A carregar...

Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

The catalytic intermediates of DNA topoisomerase I (top1) are cleavage complexes that can relax DNA supercoiling (intramolecular reaction) or mediate recombinations (intermolecular religation). We report here that DNA adducts formed from benzo[a]pyrene bay-region diol epoxides can markedly affect to...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pommier, Yves, Kohlhagen, Glenda, Pourquier, Philippe, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15750/
https://ncbi.nlm.nih.gov/pubmed/10688881
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!