Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

The catalytic intermediates of DNA topoisomerase I (top1) are cleavage complexes that can relax DNA supercoiling (intramolecular reaction) or mediate recombinations (intermolecular religation). We report here that DNA adducts formed from benzo[a]pyrene bay-region diol epoxides can markedly affect to...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Pommier, Yves, Kohlhagen, Glenda, Pourquier, Philippe, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040397497
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