Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate

Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of...

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Bibliographic Details
Main Authors: Meehan, Thomas, Wolfe, Alan R., Negrete, George R., Song, Qi
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19988/
https://ncbi.nlm.nih.gov/pubmed/9050850
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